Interaction between Toxoplasma gondii and HIV during pregnancy [Interacción entre Toxoplasma gondii y VIH en la Gestación]
DOI:
https://doi.org/10.62574/drgvxd07Keywords:
coinfection, vertical transmission of infectious disease, HIV infectionsAbstract
Objective: To analyse the interaction between Toxoplasma gondii and HIV during pregnancy. Method: systematic review of 20 documents. Results and conclusion: Coinfection with toxoplasmosis and HIV during pregnancy is a complex clinical challenge that goes beyond simple immunosuppression, involving specific molecular mechanisms that facilitate parasite reactivation and significantly increase the risk of vertical transmission with devastating consequences for foetal development. The convergence of immunological factors specific to pregnancy, HIV-induced immunodeficiency, and the intrinsic virulence of Toxoplasma gondii requires a comprehensive approach that combines preconception preventive strategies, specific diagnostic protocols incorporating advanced molecular techniques, and treatments aimed at interrupting the pathogenic interaction between the two pathogens.
Downloads
References
Dunn D, Wallon M, Peyron F, et al. Mother-to-child transmission of toxoplasmosis: risk estimates for clinical counselling. Lancet. 1999;353(9167):1829–33. Disponible en: https://doi.org/10.1016/S0140-6736(98)31334-4
Jones JL, Lopez A, Wilson M. Congenital toxoplasmosis. Am Fam Physician. 2003;67(10):2131–8. Disponible en: https://www.aafp.org/pubs/afp/issues/2003/0515/p2131.html
Luft BJ, Remington JS. Toxoplasmic encephalitis in AIDS. Clin Infect Dis. 1992;15(2):211–22. Disponible en: https://doi.org/10.1093/clind/15.2.211
Kaplan JE, Benson C, Holmes KK, et al. Guidelines for prevention and treatment of opportunistic infections in HIV-infected adults and adolescents. MMWR Recomm Rep. 2009;58(RR-4):1–207. Disponible en: https://www.cdc.gov/mmwr/preview/mmwrhtml/rr5804a1.htm
Montoya JG, Remington JS. Management of Toxoplasma gondii infection during pregnancy. Clin Infect Dis. 2008;47(4):554–66. Disponible en: https://doi.org/10.1086/590149
Gilbert RE, Gras L, Wallon M, et al. Effect of prenatal treatment on the risk of intracranial and ocular lesions in children with congenital toxoplasmosis. Eur J Pediatr. 2001;160(5):339–44. Disponible en: https://doi.org/10.1007/s004310100735
Thiébaut R, Leproust S, Chêne G, et al. Effectiveness of prenatal treatment for congenital toxoplasmosis: a meta-analysis of individual patients’ data. Lancet. 2007;369(9556):115–22. Disponible en: https://doi.org/10.1016/S0140-6736(07)60072-5
Montoya JG, Remington JS. Management of Toxoplasma gondii infection during pregnancy. Clin Infect Dis. 2008;47(4):554–66. Disponible en: https://doi.org/10.1086/590149
McLeod R, Boyer K, Karrison T, et al. Outcome of treatment for congenital toxoplasmosis, 1981–2004: the National Collaborative Chicago-Based, Congenital Toxoplasmosis Study. Clin Infect Dis. 2006;42(10):1383–94. Disponible en: https://doi.org/10.1086/501360
Kieffer F, Wallon M. Congenital toxoplasmosis. Handb Clin Neurol. 2013;112:1099–101. Disponible en: https://doi.org/10.1016/B978-0-444-52910-7.00027-5
Olariu TR, Remington JS, McLeod R, et al. Severe congenital toxoplasmosis in the United States: clinical and serologic findings in untreated infants. Pediatr Infect Dis J. 2011;30(12):1056–61. Disponible en: https://doi.org/10.1097/INF.0b013e318234a937
Prusa AR, Kasper DC, Pollak A, et al. The Austrian Toxoplasmosis Register, 1992–2008. Clin Infect Dis. 2015;60(2):e4–10. Disponible en: https://doi.org/10.1093/cid/ciu764
Stillwaggon E, Carrier CS, Sautter M, et al. Maternal serologic screening to prevent congenital toxoplasmosis: a decision-analytic economic model. PLoS Negl Trop Dis. 2011;5(9):e1333. Disponible en: https://doi.org/10.1371/journal.pntd.0001333
Foulon W, Villena I, Stray-Pedersen B, et al. Treatment of toxoplasmosis during pregnancy: a multicenter study of impact on fetal transmission and children’s sequelae at age 1 year. Am J Obstet Gynecol. 1999;180(2 Pt 1):410–5. Disponible en: https://doi.org/10.1016/S0002-9378(99)70224-6
Robert-Gangneux F, Dardé ML. Epidemiology of and diagnostic strategies for toxoplasmosis. Clin Microbiol Rev. 2012;25(2):264–96. Disponible en: https://doi.org/10.1128/CMR.05013-11
Boyer KM, Holfels E, Roizen N, et al. Risk factors for Toxoplasma gondii infection in mothers of infants with congenital toxoplasmosis: implications for prenatal management and screening. Am J Obstet Gynecol. 2005;192(2):564–71. Disponible en: https://doi.org/10.1016/j.ajog.2004.07.0
Cortina-Borja M, Tan HK, Wallon M, et al. Prenatal treatment for serious neurological sequelae of congenital toxoplasmosis: an observational prospective cohort study. PLoS Med. 2010;7(10):e1000351. Disponible en: https://doi.org/10.1371/journal.pmed.1000351
Peyron F, Wallon M, Liou C, et al. Treatments for toxoplasmosis in pregnancy. Cochrane Database Syst Rev. 2000;(2):CD001684. Disponible en: https://doi.org/10.1002/14651858.CD001684
Gras L, Gilbert RE, Wallon M, et al. Duration of the IgM response in women acquiring Toxoplasma gondii during pregnancy: implications for clinical practice and cross-sectional incidence studies. Epidemiol Infect. 2004;132(3):541–8. Disponible en: https://doi.org/10.1017/S0950268804002023
Wallon M, Franck J, Thulliez P, et al. Accuracy of real-time polymerase chain reaction for Toxoplasma gondii in amniotic fluid. Obstet Gynecol. 2010;115(4):727–33. Disponible en: https://doi.org/10.1097/AOG.0b013e3181d041cd
Downloads
Published
Issue
Section
License
Copyright (c) 2025 Silvia del Pilar Nuñez-Arroba, Micaela Judith Lliguay-Guanga , Dafne Lizeth Sánchez-Carrasco , Stefany Jackeline Vidal-Garcés (Autor/a)
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
CC BY-NC-SA : Esta licencia permite a los reutilizadores distribuir, remezclar, adaptar y construir sobre el material en cualquier medio o formato solo con fines no comerciales, y solo siempre y cuando se dé la atribución al creador. Si remezcla, adapta o construye sobre el material, debe licenciar el material modificado bajo términos idénticos.
