Conjunctival melanoma. Clinical case [Melanoma conjuntival. Caso clínico]

Authors

DOI:

https://doi.org/10.62574/j7r8ht19

Keywords:

melanoma, sarcoma clear cell, eye

Abstract

Objective: To present a clinical case of conjunctival melanoma in an 82-year-old patient. Method: Clinical case. Results and conclusion: The present clinical case of conjunctival melanoma in an 82-year-old patient highlights the importance of early diagnosis and timely surgical management in this rare but highly aggressive malignant neoplasm. Enucleation of the eyeball was imperative due to the compromised surgical margins and the invasive nature of the lesion, emphasising the need for a comprehensive multidisciplinary approach.

Downloads

Download data is not yet available.

References

Auw-Hädrich C, Reinhard T. Konjunktivale Malignome [Conjunctival malignancies]. Der Ophthalmologe. 2019;116(10):989-1004. doi:10.1007/s00347-019-00978-6.

Montazer F, et al. Conjunctival Melanoma: A Case Presentation. Iranian Journal of Pathology. 2023;18(4):488-491. doi:10.30699/IJP.2023.557981.2941.

Shields CL, et al. Conjunctival melanoma: Insights into classification, outcomes, and biomarkers. Clinics in Dermatology. 2024;42(1):46-55. doi:10.1016/j.clindermatol.2023.10.010.

Bresler SC, et al. Lesiones melanocíticas conjuntivales. Archivos de Patología y Medicina de Laboratorio. 2022;146(5):632-646. doi:10.5858/arpa.2021-0006-RA.

Milman T, et al. Nevos conjuntivales y melanoma: análisis inmunohistoquímico multiparamétrico, incluidos p16, SOX10, HMB45 y Ki-67. Patología Humana. 2020;103:107-119. doi:10.1016/j.humpath.2020.07.020.

Mikkelsen LH, et al. The molecular profile of mucosal melanoma. Melanoma Research. 2020;30(6):533-542. doi:10.1097/CMR.0000000000000686.

Lassalle S, et al. PD-L1 Expression in 65 Conjunctival Melanomas and Its Association with Clinical Outcome. International Journal of Molecular Sciences. 2020;21(23):9147. doi:10.3390/ijms21239147.

Brouwer NJ, et al. Pigmentación de las recurrencias del melanoma conjuntival y evolución. Archivo de Graefe para Oftalmología Clínica y Experimental. 2019;257(8):1783-1788. doi:10.1007/s00417-019-04342-x.

Arockiaraj BM, et al. Ambient ultraviolet radiation and ocular melanoma incidence in the United States, 2000-2019. Eye (London, England). 2024;38(9):1618-1625. doi:10.1038/s41433-024-02959-9.

Arya D, et al. Ipsilateral presentation of ocular surface squamous neoplasia and conjunctival melanoma in xeroderma pigmentosum: A rare occurrence. Indian Journal of Ophthalmology. 2019;67(12):2068-2071. doi:10.4103/ijo.IJO_1449_19.

Vazquez-Romo KA, et al. Conjunctival melanoma: Opportune detection and resolution of a fast-growing conjunctival lesion. Journal Français d'Ophtalmologie. 2020;43(8):823-824. doi:10.1016/j.jfo.2020.01.005.

Dalvin LA, et al. Conjunctival Melanoma: Outcomes Based on Age at Presentation in 629 Patients at a Single Ocular Oncology Center. Cornea. 2021;40(5):554-563. doi:10.1097/ICO.0000000000002449.

Usui Y, et al. Direct Evidence of Conjunctival Melanoma Metastasis via Lymphatic Vessel. Ophthalmology. 2023;130(10):1014. doi:10.1016/j.ophtha.2022.10.004.

Shields CL, et al. Conjunctival Melanoma: Outcomes based on the American Joint Committee on Cancer Clinical Classification (8th Edition) of 425 Patients at a Single Ocular Oncology Center. Asia-Pacific Journal of Ophthalmology (Philadelphia, Pa.). 2020;10(2):146-151. doi:10.1097/APO.0000000000000343.

Tóth G, et al. Pigmentsejt-eredetű szemfelszíni elváltozások differenciáldiagnózisa és kezelése [Differential diagnosis and management of melanocytic lesions of the ocular surface]. Orvosi Hetilap. 2020;161(15):563-574. doi:10.1556/650.2020.31699.

Hohnen H, et al. Conjunctival combined deep penetrating naevus: a clinicopathological report. Pathology. 2023;55(5):721-723. doi:10.1016/j.pathol.2023.01.008.

Wang YC, et al. [Zhonghua yan ke za zhi] Chinese Journal of Ophthalmology. 2024;60(1):64-71. doi:10.3760/cma.j.cn112142-20231013-00136.

Liu X, et al. Clinical features and prognosis of patients with metastatic ocular and orbital melanoma: A bi-institutional study. Cancer Medicine. 2023;12(15):16163-16172. doi:10.1002/cam4.6273.

Chen PY, et al. Conjunctival melanoma: A 20-year survey in a comprehensive medical center. Journal of the Formosan Medical Association. 2021;120(1 Pt 1):250-255. doi:10.1016/j.jfma.2020.04.032.

Koç İ, Kıratlı H. Current Management of Conjunctival Melanoma Part 2: Treatment and Future Directions. Turkish Journal of Ophthalmology. 2020;50(6):362-370. doi:10.4274/tjo.galenos.2020.22567.

Cid-Bertomeu P, Huerva V. Use of interferon alpha 2b to manage conjunctival primary acquired melanosis and conjunctival melanoma. Survey of Ophthalmology. 2022;67(5):1391-1404. doi:10.1016/j.survophthal.2022.03.003.

Brouwer NJ, et al. Targeting the YAP/TAZ Pathway in Uveal and Conjunctival Melanoma With Verteporfin. Investigative Ophthalmology & Visual Science. 2021;62(4):3. doi:10.1167/iovs.62.4.3.

Published

2024-12-09

Issue

Section

Clinical communications

How to Cite

1.
León-Pallasco DA, Paredes-Tobar OS, Pérez-Padilla CA, Herrera-Lazo ZDC. Conjunctival melanoma. Clinical case [Melanoma conjuntival. Caso clínico]. SRS [Internet]. 2024 Dec. 9 [cited 2026 Jul. 27];3(medicina_Ambato):23-30. Available from: https://www.revistasinstitutoperspectivasglobales.rperspectivasinvestigativas.org/index.php/sanitas/article/view/488